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10.1111/dom.12514 http://scihub22266oqcxt.onion/10.1111/dom.12514 C4560116!4560116 !26332962     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26332962 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26332962 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Diabetes+Obes+Metab 2015 ; 17 Suppl 1 (0 1 ): 6-11 Nephropedia Template TP {{tp|p=26332962 |t=2015. Molecular components of the circadian clock in mammals |pdf=|usr=}}{{26332962 }} gab.com Text Molecular components of the circadian clock in mammals JO: Diabetes Obes Metab http://www.kidney.de/pget.php?&tw=1&pmid=26332962 #FOAvip The circadian clock mechanism in animals involves a transcriptional feedback loop in which the bHLH-PAS proteins CLOCK and BMAL1 form a transcriptional activator complex to activate the transcription of the Period and Cryptochrome genes, which in turn feed back to repress their own transcription. In the mouse liver, CLOCK and BMAL1 interact with the regulatory regions of thousands of genes, which are both cyclically and constitutively expressed. The circadian transcription in the liver is clustered in phase and this is accompanied by circadian occupancy of RNA polymerase II recruitment and initiation. These changes also lead to circadian fluctuations in histone H3 lysine4 trimethylation (H3K4me3) as well as H3 lysine9 acetylation (H3K9ac) and H3 lysine27 acetylation (H3K27ac). Thus, the circadian clock regulates global transcriptional poise and chromatin state by regulation of RNA polymerase II. Twit Text FOAVip Molecular components of the circadian clock in mammals ????Diabetes Obes Metab http://www.kidney.de/pget.php?&tw=1&pmid=26332962 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26332962 #FOAvip English Wikipedia <ref>{{Cite pmid|26332962 }}</ref> Molecular components of the circadian clock in mammals #MMPMID26332962 Takahashi JS Diabetes Obes Metab 2015[Sep]; 17 Suppl 1 (0 1 ): 6-11 PMID26332962 show ga The circadian clock mechanism in animals involves a transcriptional feedback loop in which the bHLH-PAS proteins CLOCK and BMAL1 form a transcriptional activator complex to activate the transcription of the Period and Cryptochrome genes, which in turn feed back to repress their own transcription. In the mouse liver, CLOCK and BMAL1 interact with the regulatory regions of thousands of genes, which are both cyclically and constitutively expressed. The circadian transcription in the liver is clustered in phase and this is accompanied by circadian occupancy of RNA polymerase II recruitment and initiation. These changes also lead to circadian fluctuations in histone H3 lysine4 trimethylation (H3K4me3) as well as H3 lysine9 acetylation (H3K9ac) and H3 lysine27 acetylation (H3K27ac). Thus, the circadian clock regulates global transcriptional poise and chromatin state by regulation of RNA polymerase II. |ARNTL Transcription Factors/*genetics/physiology [MESH] |Acetylation [MESH] |Animals [MESH] |Basic Helix-Loop-Helix Transcription Factors/genetics [MESH] |CLOCK Proteins/*genetics/physiology [MESH] |Circadian Clocks/*genetics [MESH] |Gene Expression [MESH] |Histones/metabolism [MESH] |Humans [MESH] |Liver/physiology [MESH] |Lysine/metabolism [MESH] |Mammals/*genetics [MESH] |Mice [MESH] |Models, Biological [MESH] |RNA Polymerase II/metabolism [MESH]Molecular components of the circadian clock in mammals (epmc).pdf DeepDyve Pubget Overpricing