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2014 ; 19
(ä): 84-9
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Molecular aspects of tight junction barrier function
#MMPMID25128899
Liang GH
; Weber CR
Curr Opin Pharmacol
2014[Dec]; 19
(ä): 84-9
PMID25128899
show ga
In complex multicellular organisms, epithelia lining body cavities regulate
absorption and secretion of ions, organic molecules, and water. Proper function
of epithelia depends on apically and basolaterally situated ion channels as well
as tight junctions which seal the apical intercellular space. Without tight
junctions, transepithelial concentration gradients of ions and nutrients would be
dissipated through the paracellular space. Elevated tight junction permeability
is a feature of many diseases of multiple organs, including the gastrointestinal
tract [1,2,3(?),4(?)], kidney [5,6], and lungs [7,8]. In the intestines,
epithelial barrier dysfunction is a major contributor to diarrhea and
malnutrition and is associated with significant morbidity and mortality
worldwide.