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2015 ; 2015
(ä): 378675
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Molecular and functional imaging of internet addiction
#MMPMID25879023
Zhu Y
; Zhang H
; Tian M
Biomed Res Int
2015[]; 2015
(ä): 378675
PMID25879023
show ga
Maladaptive use of the Internet results in Internet addiction (IA), which is
associated with various negative consequences. Molecular and functional imaging
techniques have been increasingly used for analysis of neurobiological changes
and neurochemical correlates of IA. This review summarizes molecular and
functional imaging findings on neurobiological mechanisms of IA, focusing on
magnetic resonance imaging (MRI) and nuclear imaging modalities including
positron emission tomography (PET) and single photon emission computed tomography
(SPECT). MRI studies demonstrate that structural changes in frontal cortex are
associated with functional abnormalities in Internet addicted subjects. Nuclear
imaging findings indicate that IA is associated with dysfunction of the brain
dopaminergic systems. Abnormal dopamine regulation of the prefrontal cortex (PFC)
could underlie the enhanced motivational value and uncontrolled behavior over
Internet overuse in addicted subjects. Further investigations are needed to
determine specific changes in the Internet addictive brain, as well as their
implications for behavior and cognition.
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