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2016 ; 11
(3
): e0150540
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Molecular Structure of Human-Liver Glycogen
#MMPMID26934359
Deng B
; Sullivan MA
; Chen C
; Li J
; Powell PO
; Hu Z
; Gilbert RG
PLoS One
2016[]; 11
(3
): e0150540
PMID26934359
show ga
Glycogen is a highly branched glucose polymer which is involved in maintaining
blood-sugar homeostasis. Liver glycogen contains large composite ? particles made
up of linked ? particles. Previous studies have shown that the binding which
links ? particles into ? particles is impaired in diabetic mice. The present
study reports the first molecular structural characterization of human-liver
glycogen from non-diabetic patients, using transmission electron microscopy for
morphology and size-exclusion chromatography for the molecular size distribution;
the latter is also studied as a function of time during acid hydrolysis in vitro,
which is sensitive to certain structural features, particularly glycosidic vs.
proteinaceous linkages. The results are compared with those seen in mice and
pigs. The molecular structural change during acid hydrolysis is similar in each
case, and indicates that the linkage of ? into ? particles is not glycosidic.
This result, and the similar morphology in each case, together imply that human
liver glycogen has similar molecular structure to those of mice and pigs. This
knowledge will be useful for future diabetes drug targets.
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