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10.1158/1078-0432.CCR-16-0934 http://scihub22266oqcxt.onion/10.1158/1078-0432.CCR-16-0934 C5413367!5413367 !28087641     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28087641 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Cancer+Res 2017 ; 23 (9 ): 2136-2142 Nephropedia Template TP {{tp|p=28087641 |t=2017. Molecular Pathways: Targeting Protein Tyrosine Phosphatases in Cancer |pdf=|usr=}}{{28087641 }} gab.com Text Molecular Pathways: Targeting Protein Tyrosine Phosphatases in Cancer JO: Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28087641 #FOAvip The aberrant activation of oncogenic signaling pathways is a universal phenomenon in cancer and drives tumorigenesis and malignant transformation. This abnormal activation of signaling pathways in cancer is due to the altered expression of protein kinases and phosphatases. In response to extracellular signals, protein kinases activate downstream signaling pathways through a series of protein phosphorylation events, ultimately producing a signal response. Protein tyrosine phosphatases (PTP) are a family of enzymes that hydrolytically remove phosphate groups from proteins. Initially, PTPs were shown to act as tumor suppressor genes by terminating signal responses through the dephosphorylation of oncogenic kinases. More recently, it has become clear that several PTPs overexpressed in human cancers do not suppress tumor growth; instead, they positively regulate signaling pathways and promote tumor development and progression. In this review, we discuss both types of PTPs: those that have tumor suppressor activities as well as those that act as oncogenes. We also discuss the potential of PTP inhibitors for cancer therapy. Clin Cancer Res; 23(9); 2136-42. ©2017 AACR. Twit Text FOAVip Molecular Pathways: Targeting Protein Tyrosine Phosphatases in Cancer ????Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28087641 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28087641 #FOAvip English Wikipedia <ref>{{Cite pmid|28087641 }}</ref> Molecular Pathways: Targeting Protein Tyrosine Phosphatases in Cancer #MMPMID28087641 Bollu LR ; Mazumdar A ; Savage MI ; Brown PH Clin Cancer Res 2017[May]; 23 (9 ): 2136-2142 PMID28087641 show ga The aberrant activation of oncogenic signaling pathways is a universal phenomenon in cancer and drives tumorigenesis and malignant transformation. This abnormal activation of signaling pathways in cancer is due to the altered expression of protein kinases and phosphatases. In response to extracellular signals, protein kinases activate downstream signaling pathways through a series of protein phosphorylation events, ultimately producing a signal response. Protein tyrosine phosphatases (PTP) are a family of enzymes that hydrolytically remove phosphate groups from proteins. Initially, PTPs were shown to act as tumor suppressor genes by terminating signal responses through the dephosphorylation of oncogenic kinases. More recently, it has become clear that several PTPs overexpressed in human cancers do not suppress tumor growth; instead, they positively regulate signaling pathways and promote tumor development and progression. In this review, we discuss both types of PTPs: those that have tumor suppressor activities as well as those that act as oncogenes. We also discuss the potential of PTP inhibitors for cancer therapy. Clin Cancer Res; 23(9); 2136-42. ©2017 AACR. |*Molecular Targeted Therapy [MESH] |Carcinogenesis/*genetics [MESH] |Genes, Tumor Suppressor [MESH] |Humans [MESH] |Neoplasms/*enzymology/genetics [MESH] |Phosphorylation [MESH] |Protein Processing, Post-Translational/genetics [MESH] |Protein Tyrosine Phosphatases/*genetics/therapeutic use [MESH]Molecular Pathways: Targeting Protein Tyrosine Phosphatases in Cancer (epmc).pdf DeepDyve Pubget Overpricing