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2018 ; 10
(6
): ä Nephropedia Template TP
Afonso MS
; Machado RM
; Lavrador MS
; Quintao ECR
; Moore KJ
; Lottenberg AM
Nutrients
2018[Jun]; 10
(6
): ä PMID29899250
show ga
Cholesterol is an essential molecule that exerts pleiotropic actions. Although
its presence is vital to the cell, its excess can be harmful and, therefore,
sustaining cholesterol homeostasis is crucial to maintaining proper cellular
functioning. It is well documented that high plasma cholesterol concentration
increases the risk of atherosclerotic heart disease. In the last decades, several
studies have investigated the association of plasma cholesterol concentrations
and the risk of cardiovascular diseases as well as the signaling pathways
involved in cholesterol homeostasis. Here, we present an overview of several
mechanisms involved in intestinal cholesterol absorption, the regulation of
cholesterol synthesis and uptake. We also discuss the importance of reverse
cholesterol transport and transintestinal cholesterol transport to maintain
cholesterol homeostasis and prevent atherosclerosis development. Additionally, we
discuss the influence of dietary cholesterol on plasma cholesterol concentration
and the new recommendations for cholesterol intake in a context of a healthy
dietary pattern.
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