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2015 ; 2015
(ä): 643409
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Molecular Pathogenesis of Anti-NMDAR Encephalitis
#MMPMID26221602
Ding H
; Jian Z
; Stary CM
; Yi W
; Xiong X
Biomed Res Int
2015[]; 2015
(ä): 643409
PMID26221602
show ga
Anti-NMDAR encephalitis is a recently identified autoimmune disease, described by
an immune-mediated loss of NMDA glutamate receptors, resulting in progressive
mental deterioration. To date, literature on anti-NMDAR encephalitis has been
largely clinically oriented, including descriptions of the clinical presentation
and course, diagnostic methods, and potential clinical treatments. However, the
underlying molecular mechanisms contributing to the complex immunological
cellular transformation that is associated with the progression of anti-NMDAR
encephalitis remain to be adequately explored. This review will provide a summary
of the current literature on anti-NMDAR encephalitis, including the immunologic
molecular mechanisms contributing to disease progression. In particular this
review will focus on the effect of anti-NMDAR on GluN2-NMDAR expression and the
molecular transformation of B and T leukocytes in the loss of self-tolerance.
Further research on the immunologic mechanisms contributing to anti-NMDAR
encephalitis may provide an avenue for future novel diagnostic approaches, such
as immunologic surveillance, as well as new therapeutic strategies for this
recently identified autoimmune disease.
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