Molecular Diagnostic Testing for Aspergillus
#MMPMID27487954
Powers-Fletcher MV
; Hanson KE
J Clin Microbiol
2016[Nov]; 54
(11
): 2655-2660
PMID27487954
show ga
The direct detection of Aspergillus nucleic acid in clinical specimens has the
potential to improve the diagnosis of aspergillosis by offering more rapid and
sensitive identification of invasive infections than is possible with traditional
techniques, such as culture or histopathology. Molecular tests for Aspergillus
have been limited historically by lack of standardization and variable
sensitivities and specificities. Recent efforts have been directed at addressing
these limitations and optimizing assay performance using a variety of specimen
types. This review provides a summary of standardization efforts and outlines the
complexities of molecular testing for Aspergillus in clinical mycology.