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2016 ; 7
(ä): 1419
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Molecular Biology and Infection of Hepatitis E Virus
#MMPMID27656178
Nan Y
; Zhang YJ
Front Microbiol
2016[]; 7
(ä): 1419
PMID27656178
show ga
Hepatitis E virus (HEV) is a viral pathogen transmitted primarily via fecal-oral
route. In humans, HEV mainly causes acute hepatitis and is responsible for large
outbreaks of hepatitis across the world. The case fatality rate of HEV-induced
hepatitis ranges from 0.5 to 3% in young adults and up to 30% in infected
pregnant women. HEV strains infecting humans are classified into four genotypes.
HEV strains from genotypes 3 and 4 are zoonotic, whereas those from genotypes 1
and 2 have no known animal reservoirs. Recently, notable progress has been
accomplished for better understanding of HEV biology and infection, such as
chronic HEV infection, in vitro cell culture system, quasi-enveloped HEV virions,
functions of the HEV proteins, mechanism of HEV antagonizing host innate
immunity, HEV pathogenesis and vaccine development. However, further
investigation on the cross-species HEV infection, host tropism, vaccine efficacy,
and HEV-specific antiviral strategy is still needed. This review mainly focuses
on molecular biology and infection of HEV and offers perspective new insight of
this enigmatic virus.
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