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Mold infections of the central nervous system
#MMPMID25006721
McCarthy M
; Rosengart A
; Schuetz AN
; Kontoyiannis DP
; Walsh TJ
N Engl J Med
2014[Jul]; 371
(2
): 150-60
PMID25006721
show ga
The recent outbreak of exserohilum rostratum meningitis linked to epidural
injections of methylprednisolone acetate has brought renewed attention to mold
infections of the central nervous system (CNS). Although uncommon, these
infections are often devastating and difficult to treat. This focused review of
the epidemiologic aspects, clinical characteristics, and treatment of mold
infections of the CNS covers a group of common pathogens: aspergillus, fusarium,
and scedosporium species, molds in the order Mucorales, and dematiaceous molds.
Infections caused by these pathogen groups have distinctive epidemiologic
profiles, clinical manifestations, microbiologic characteristics, and therapeutic
implications, all of which clinicians should understand.
|*Central Nervous System Fungal Infections/diagnosis/drug
therapy/immunology/surgery
[MESH]