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10.1002/wnan.1406 http://scihub22266oqcxt.onion/10.1002/wnan.1406 C5045752!5045752 !27038329     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27038329 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27038329 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Wiley+Interdiscip+Rev+Nanomed+Nanobiotechnol 2016 ; 8 (6 ): 891-908 Nephropedia Template TP {{tp|p=27038329 |t=2016. Modifying the tumor microenvironment using nanoparticle therapeutics |pdf=|usr=}}{{27038329 }} gab.com Text Modifying the tumor microenvironment using nanoparticle therapeutics JO: Wiley Interdiscip Rev Nanomed Nanobiotechnol http://www.kidney.de/pget.php?&tw=1&pmid=27038329 #FOAvip Treatment of cancer has come a long way from the initial 'radical surgeries' to the multimodality treatments. For the major part of the last century, cancer was considered as a monocellular disorder, and treatment strategies were designed according to that hypothesis. However, the mortality rate from cancer continued to be high and a comprehensive treatment remained elusive. Recent progress in research has demonstrated that tumors are a complex network of neoplastic and non-neoplastic cells. The non-neoplastic cells, which are collectively called stroma, assist in tumor survival and progression. It has been shown that disrupting the tumor-stromal balance leads to significant effects on the tumor survival, and effective treatment can be achieved by targeting one or more of the stromal components. In this review, we summarize the roles of various stromal components in promoting tumor progression, and discuss innovative nanoparticle-mediated drug targeting strategies for stromal depletion and the subsequent effects on the tumors. Perspectives and the future directions are also provided. WIREs Nanomed Nanobiotechnol 2016, 8:891-908. doi: 10.1002/wnan.1406 For further resources related to this article, please visit the WIREs website. Twit Text FOAVip Modifying the tumor microenvironment using nanoparticle therapeutics ????Wiley Interdiscip Rev Nanomed Nanobiotechnol http://www.kidney.de/pget.php?&tw=1&pmid=27038329 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27038329 #FOAvip English Wikipedia <ref>{{Cite pmid|27038329 }}</ref> Modifying the tumor microenvironment using nanoparticle therapeutics #MMPMID27038329 Roy A ; Li SD Wiley Interdiscip Rev Nanomed Nanobiotechnol 2016[Nov]; 8 (6 ): 891-908 PMID27038329 show ga Treatment of cancer has come a long way from the initial 'radical surgeries' to the multimodality treatments. For the major part of the last century, cancer was considered as a monocellular disorder, and treatment strategies were designed according to that hypothesis. However, the mortality rate from cancer continued to be high and a comprehensive treatment remained elusive. Recent progress in research has demonstrated that tumors are a complex network of neoplastic and non-neoplastic cells. The non-neoplastic cells, which are collectively called stroma, assist in tumor survival and progression. It has been shown that disrupting the tumor-stromal balance leads to significant effects on the tumor survival, and effective treatment can be achieved by targeting one or more of the stromal components. In this review, we summarize the roles of various stromal components in promoting tumor progression, and discuss innovative nanoparticle-mediated drug targeting strategies for stromal depletion and the subsequent effects on the tumors. Perspectives and the future directions are also provided. WIREs Nanomed Nanobiotechnol 2016, 8:891-908. doi: 10.1002/wnan.1406 For further resources related to this article, please visit the WIREs website. |*Antineoplastic Agents [MESH] |*Nanoparticles [MESH] |Animals [MESH] |Humans [MESH] |Mice [MESH] |Nanomedicine/*methods [MESH]Modifying the tumor microenvironment using nanoparticle therapeutics (epmc).pdf DeepDyve Pubget Overpricing