Models of disease behavior in idiopathic pulmonary fibrosis
#MMPMID26400574
Johannson KA
; Ley B
; Collard HR
BMC Med
2015[Sep]; 13
(?): 165
PMID26400574
show ga
Idiopathic pulmonary fibrosis is a diffuse parenchymal lung disease of unknown
cause. The natural history of disease can vary considerably, making it difficult
to predict the clinical trajectory for an individual patient. Accurate
prognostication is desirable for clinical management as well as for cohort
enrichment in clinical trials of therapeutics. Clinical and biomarker models of
disease behavior have been developed to improve prognostication in idiopathic
pulmonary fibrosis, with moderate predictive capabilities. Integrated prediction
models that combine both clinical and biomarker variables will improve
prognostication for patients and improved cohort enrichment strategies for
clinical trials. This goal may be best achieved through collaborative patient
registries with prospectively collected biological samples that allow for
characterization of disease behavior in idiopathic pulmonary fibrosis.