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10.1111/bcpt.70073 http://scihub22266oqcxt.onion/10.1111/bcpt.70073 40642781!ä!40642781 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\40642781.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Basic+Clin+Pharmacol+Toxicol 2025 ; 137 (2): e70073 Nephropedia Template TP {{tp|p=40642781|t=2025. Models of Endocrine-Disrupting Effects: Human Placental Steroidogenesis |pdf=|usr=}}{{40642781}} gab.com Text Models of Endocrine-Disrupting Effects: Human Placental Steroidogenesis JO: Basic Clin Pharmacol Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=40642781 #FOAvip Endocrine disruption during pregnancy has gained increasing interest as epidemiological studies report associations of exposures and adverse effects on fetal growth, followed by effects on the growing child and ultimately in the adult. When studying endocrine disruption during pregnancy, the placental steroidogenesis is difficult to model, as the human placenta is unique in the pathway of cellular uptake of cholesterol, the high levels of progesterone production and the expression of aromatase. Models to test for endocrine disruption should respect species differences, with preference to human models for human risk assessment. Here, we present existing research of placental steroidogenesis and other placental hormones using human placental models: placental perfusion, placental explants, fragments, microsomes and vesicles, primary cell culture, stem cells, placenta on a chip and choriocarcinoma cell cultures: BeWo, HTR-8/SVneo, Jar, JEG-3 and ACH-3P. We conclude that there is a lack of research focused on placental steroidogenesis and the effects of endocrine-disrupting compounds. Advantages and limitations of existing models are discussed, and future directions suggested. Twit Text FOAVip Models of Endocrine-Disrupting Effects: Human Placental Steroidogenesis ????Basic Clin Pharmacol Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=40642781 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40642781 #FOAvip English Wikipedia <ref>{{Cite pmid|40642781}}</ref> Models of Endocrine-Disrupting Effects: Human Placental Steroidogenesis #MMPMID40642781 Mathiesen L; Sandal D; Hammer IEM; Styrishave B; Knudsen LE Basic Clin Pharmacol Toxicol 2025[Aug]; 137 (2): e70073 PMID40642781show ga Endocrine disruption during pregnancy has gained increasing interest as epidemiological studies report associations of exposures and adverse effects on fetal growth, followed by effects on the growing child and ultimately in the adult. When studying endocrine disruption during pregnancy, the placental steroidogenesis is difficult to model, as the human placenta is unique in the pathway of cellular uptake of cholesterol, the high levels of progesterone production and the expression of aromatase. Models to test for endocrine disruption should respect species differences, with preference to human models for human risk assessment. Here, we present existing research of placental steroidogenesis and other placental hormones using human placental models: placental perfusion, placental explants, fragments, microsomes and vesicles, primary cell culture, stem cells, placenta on a chip and choriocarcinoma cell cultures: BeWo, HTR-8/SVneo, Jar, JEG-3 and ACH-3P. We conclude that there is a lack of research focused on placental steroidogenesis and the effects of endocrine-disrupting compounds. Advantages and limitations of existing models are discussed, and future directions suggested. |*Endocrine Disruptors/toxicity[MESH] |*Placenta/metabolism/drug effects[MESH] |*Placental Hormones/biosynthesis[MESH] |*Steroids/biosynthesis[MESH] |Female[MESH] |Humans[MESH] |Models, Biological[MESH] |Pregnancy[MESH]Models of Endocrine-Disrupting Effects: Human Placental Steroidogenesi(epmc).pdf DeepDyve Pubget Overpricing