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10.1371/journal.pone.0174538 http://scihub22266oqcxt.onion/10.1371/journal.pone.0174538 C5367812!5367812 !28346525     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28346525 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2017 ; 12 (3 ): e0174538 Nephropedia Template TP {{tp|p=28346525 |t=2017. Modeling timelines for translational science in cancer; the impact of technological maturation |pdf=|usr=}}{{28346525 }} gab.com Text Modeling timelines for translational science in cancer; the impact of technological maturation JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28346525 #FOAvip This work examines translational science in cancer based on theories of innovation that posit a relationship between the maturation of technologies and their capacity to generate successful products. We examined the growth of technologies associated with 138 anticancer drugs using an analytical model that identifies the point of initiation of exponential growth and the point at which growth slows as the technology becomes established. Approval of targeted and biological products corresponded with technological maturation, with first approval averaging 14 years after the established point and 44 years after initiation of associated technologies. The lag in cancer drug approvals after the increases in cancer funding and dramatic scientific advances of the 1970s thus reflects predictable timelines of technology maturation. Analytical models of technological maturation may be used for technological forecasting to guide more efficient translation of scientific discoveries into cures. Twit Text FOAVip Modeling timelines for translational science in cancer; the impact of technological maturation ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28346525 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28346525 #FOAvip English Wikipedia <ref>{{Cite pmid|28346525 }}</ref> Modeling timelines for translational science in cancer; the impact of technological maturation #MMPMID28346525 McNamee LM ; Ledley FD PLoS One 2017[]; 12 (3 ): e0174538 PMID28346525 show ga This work examines translational science in cancer based on theories of innovation that posit a relationship between the maturation of technologies and their capacity to generate successful products. We examined the growth of technologies associated with 138 anticancer drugs using an analytical model that identifies the point of initiation of exponential growth and the point at which growth slows as the technology becomes established. Approval of targeted and biological products corresponded with technological maturation, with first approval averaging 14 years after the established point and 44 years after initiation of associated technologies. The lag in cancer drug approvals after the increases in cancer funding and dramatic scientific advances of the 1970s thus reflects predictable timelines of technology maturation. Analytical models of technological maturation may be used for technological forecasting to guide more efficient translation of scientific discoveries into cures. |*Diffusion of Innovation [MESH] |*Models, Theoretical [MESH] |*Translational Research, Biomedical [MESH] |Antineoplastic Agents/*therapeutic use [MESH] |Biotechnology [MESH] |Humans [MESH]Modeling timelines for translational science in cancer; the impact of (epmc).pdf DeepDyve Pubget Overpricing