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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Bull+Math+Biol
2016 ; 78
(6
): 1318-36
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Modeling Glucose Metabolism in the Kidney
#MMPMID27371260
Chen Y
; Fry BC
; Layton AT
Bull Math Biol
2016[Jun]; 78
(6
): 1318-36
PMID27371260
show ga
The mammalian kidney consumes a large amount of energy to support the
reabsorptive work it needs to excrete metabolic wastes and to maintain
homeostasis. Part of that energy is supplied via the metabolism of glucose. To
gain insights into the transport and metabolic processes in the kidney, we have
developed a detailed model of the renal medulla of the rat kidney. The model
represents water and solute flows, transmural fluxes, and biochemical reactions
in the luminal fluid of the nephrons and vessels. In particular, the model
simulates the metabolism of oxygen and glucose. Using that model, we have
identified parameters concerning glucose transport and basal metabolism that
yield predicted blood glucose concentrations that are consistent with
experimental measurements. The model predicts substantial axial gradients in
blood glucose levels along various medullary structures. Furthermore, the model
predicts that in the inner medulla, owing to the relatively limited blood flow
and low tissue oxygen tension, anaerobic metabolism of glucose dominates.
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