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2015 ; 25
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English Wikipedia
Mixing in microfluidic devices and enhancement methods
#MMPMID26549938
Ward K
; Fan ZH
J Micromech Microeng
2015[Sep]; 25
(9
): ä PMID26549938
show ga
Mixing in microfluidic devices presents a challenge due to laminar flows in
microchannels, which result from low Reynolds numbers determined by the channel's
hydraulic diameter, flow velocity, and solution's kinetic viscosity. To address
this challenge, novel methods of mixing enhancement within microfluidic devices
have been explored for a variety of applications. Passive mixing methods have
been created, including those using ridges or slanted wells within the
microchannels, as well as their variations with improved performance by varying
geometry and patterns, by changing the properties of channel surfaces, and by
optimization via simulations. In addition, active mixing methods including
microstirrers, acoustic mixers, and flow pulsation have been investigated and
integrated into microfluidic devices to enhance mixing in a more controllable
manner. In general, passive mixers are easy to integrate, but difficult to
control externally by users after fabrication. Active mixers usually take efforts
to integrate within a device and they require external components (e.g. power
sources) to operate. However, they can be controlled by users to a certain degree
for tuned mixing. In this article, we provide a general overview of a number of
passive and active mixers, discuss their advantages and disadvantages, and make
suggestions on choosing a mixing method for a specific need as well as advocate
possible integration of key elements of passive and active mixers to harness the
advantages of both types.
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