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10.1080/15548627.2016.1151580 http://scihub22266oqcxt.onion/10.1080/15548627.2016.1151580 C4836026!4836026 !27050458     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27050458 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Autophagy 2016 ; 12 (4 ): 689-702 Nephropedia Template TP {{tp|p=27050458 |t=2016. Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy |pdf=|usr=}}{{27050458 }} gab.com Text Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=27050458 #FOAvip Mitochondrial fragmentation due to imbalanced fission and fusion of mitochondria is a prerequisite for mitophagy, however, the exact "coupling" of mitochondrial dynamics and mitophagy remains unclear. We have previously identified that FUNDC1 recruits MAP1LC3B/LC3B (LC3) through its LC3-interacting region (LIR) motif to initiate mitophagy in mammalian cells. Here, we show that FUNDC1 interacts with both DNM1L/DRP1 and OPA1 to coordinate mitochondrial fission or fusion and mitophagy. OPA1 interacted with FUNDC1 via its Lys70 (K70) residue, and mutation of K70 to Ala (A), but not to Arg (R), abolished the interaction and promoted mitochondrial fission and mitophagy. Mitochondrial stress such as selenite or FCCP treatment caused the disassembly of the FUNDC1-OPA1 complex while enhancing DNM1L recruitment to the mitochondria. Furthermore, we observed that dephosphorylation of FUNDC1 under stress conditions promotes the dissociation of FUNDC1 from OPA1 and association with DNM1L. Our data suggest that FUNDC1 regulates both mitochondrial fission or fusion and mitophagy and mediates the "coupling" across the double membrane for mitochondrial dynamics and quality control. Twit Text FOAVip Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=27050458 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27050458 #FOAvip English Wikipedia <ref>{{Cite pmid|27050458 }}</ref> Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy #MMPMID27050458 Chen M ; Chen Z ; Wang Y ; Tan Z ; Zhu C ; Li Y ; Han Z ; Chen L ; Gao R ; Liu L ; Chen Q Autophagy 2016[]; 12 (4 ): 689-702 PMID27050458 show ga Mitochondrial fragmentation due to imbalanced fission and fusion of mitochondria is a prerequisite for mitophagy, however, the exact "coupling" of mitochondrial dynamics and mitophagy remains unclear. We have previously identified that FUNDC1 recruits MAP1LC3B/LC3B (LC3) through its LC3-interacting region (LIR) motif to initiate mitophagy in mammalian cells. Here, we show that FUNDC1 interacts with both DNM1L/DRP1 and OPA1 to coordinate mitochondrial fission or fusion and mitophagy. OPA1 interacted with FUNDC1 via its Lys70 (K70) residue, and mutation of K70 to Ala (A), but not to Arg (R), abolished the interaction and promoted mitochondrial fission and mitophagy. Mitochondrial stress such as selenite or FCCP treatment caused the disassembly of the FUNDC1-OPA1 complex while enhancing DNM1L recruitment to the mitochondria. Furthermore, we observed that dephosphorylation of FUNDC1 under stress conditions promotes the dissociation of FUNDC1 from OPA1 and association with DNM1L. Our data suggest that FUNDC1 regulates both mitochondrial fission or fusion and mitophagy and mediates the "coupling" across the double membrane for mitochondrial dynamics and quality control. |*Mitochondrial Dynamics [MESH] |*Mitophagy [MESH] |Amino Acid Sequence [MESH] |Casein Kinase II/metabolism [MESH] |Dynamins [MESH] |GTP Phosphohydrolases/metabolism [MESH] |Gene Knockdown Techniques [MESH] |HeLa Cells [MESH] |Humans [MESH] |Membrane Proteins/chemistry/*metabolism [MESH] |Microtubule-Associated Proteins/metabolism [MESH] |Mitochondria/metabolism [MESH] |Mitochondrial Proteins/chemistry/*metabolism [MESH] |Phosphorylation [MESH]Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitopha(epmc).pdf DeepDyve Pubget Overpricing