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2016 ; 9
(3
): 465-8
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Mitomycin C in pterygium treatment
#MMPMID27158622
Martins TG
; Costa AL
; Alves MR
; Chammas R
; Schor P
Int J Ophthalmol
2016[]; 9
(3
): 465-8
PMID27158622
show ga
Pterygium is a benign lesion usually growing from the nasal side of the
conjunctiva onto the cornea. Most cases of pterygium does not cause problem or
requires specific treatment. The exact cause of pterygium is not clear yet, but
some factors are pointed as causes, being the most important the long-term
ultraviolet ray exposure. Pterygium surgery is usually considered when there are
symptoms that do not respond to conservative treatment. Recurrence is the main
complication of the surgery, and much has been done to avoid it. Mitomycin C
(MMC) has been used as a fibroblast proliferation inhibitor during the surgery to
reduce the chance of recurrence of the pterygium. This review describes the use
of MMC as an adjunctive, the optimal dosage, the duration of administration of
MMC and possible complications, when used during, after and before the surgery.
Most studies suggest that increased exposure (dose or duration) of MMC is
associated with a lower recurrence, but with higher risks of complications.
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