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10.1021/pr500813f http://scihub22266oqcxt.onion/10.1021/pr500813f C4286170!4286170 !25367773     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25367773 &cmd=llinks): Failed to open stream: HTTP request failed! 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Mitochondrial targets for pharmacological intervention in human disease |pdf=|usr=}}{{25367773 }} gab.com Text Mitochondrial targets for pharmacological intervention in human disease JO: J Proteome Res http://www.kidney.de/pget.php?&tw=1&pmid=25367773 #FOAvip Over the past several years, mitochondrial dysfunction has been linked to an increasing number of human illnesses, making mitochondrial proteins (MPs) an ever more appealing target for therapeutic intervention. With 20% of the mitochondrial proteome (312 of an estimated 1500 MPs) having known interactions with small molecules, MPs appear to be highly targetable. Yet, despite these targeted proteins functioning in a range of biological processes (including induction of apoptosis, calcium homeostasis, and metabolism), very few of the compounds targeting MPs find clinical use. Recent work has greatly expanded the number of proteins known to localize to the mitochondria and has generated a considerable increase in MP 3D structures available in public databases, allowing experimental screening and in silico prediction of mitochondrial drug targets on an unprecedented scale. Here, we summarize the current literature on clinically active drugs that target MPs, with a focus on how existing drug targets are distributed across biochemical pathways and organelle substructures. Also, we examine current strategies for mitochondrial drug discovery, focusing on genetic, proteomic, and chemogenomic assays, and relevant model systems. As cell models and screening techniques improve, MPs appear poised to emerge as relevant targets for a wide range of complex human diseases, an eventuality that can be expedited through systematic analysis of MP function. Twit Text FOAVip Mitochondrial targets for pharmacological intervention in human disease ????J Proteome Res http://www.kidney.de/pget.php?&tw=1&pmid=25367773 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25367773 #FOAvip English Wikipedia <ref>{{Cite pmid|25367773 }}</ref> Mitochondrial targets for pharmacological intervention in human disease #MMPMID25367773 Malty RH ; Jessulat M ; Jin K ; Musso G ; Vlasblom J ; Phanse S ; Zhang Z ; Babu M J Proteome Res 2015[Jan]; 14 (1 ): 5-21 PMID25367773 show ga Over the past several years, mitochondrial dysfunction has been linked to an increasing number of human illnesses, making mitochondrial proteins (MPs) an ever more appealing target for therapeutic intervention. With 20% of the mitochondrial proteome (312 of an estimated 1500 MPs) having known interactions with small molecules, MPs appear to be highly targetable. Yet, despite these targeted proteins functioning in a range of biological processes (including induction of apoptosis, calcium homeostasis, and metabolism), very few of the compounds targeting MPs find clinical use. Recent work has greatly expanded the number of proteins known to localize to the mitochondria and has generated a considerable increase in MP 3D structures available in public databases, allowing experimental screening and in silico prediction of mitochondrial drug targets on an unprecedented scale. Here, we summarize the current literature on clinically active drugs that target MPs, with a focus on how existing drug targets are distributed across biochemical pathways and organelle substructures. Also, we examine current strategies for mitochondrial drug discovery, focusing on genetic, proteomic, and chemogenomic assays, and relevant model systems. As cell models and screening techniques improve, MPs appear poised to emerge as relevant targets for a wide range of complex human diseases, an eventuality that can be expedited through systematic analysis of MP function. |*Molecular Targeted Therapy [MESH] |Animals [MESH] |Drug Evaluation, Preclinical [MESH] |Humans [MESH] |Mitochondria/drug effects/*metabolism [MESH] |Mitochondrial Proteins/antagonists & inhibitors/physiology [MESH]Mitochondrial targets for pharmacological intervention in human diseas(epmc).pdf DeepDyve Pubget Overpricing