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2017 ; 50
(4
): 164-174
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Mitochondrial noncoding RNA transport
#MMPMID28115039
Kim KM
; Noh JH
; Abdelmohsen K
; Gorospe M
BMB Rep
2017[Apr]; 50
(4
): 164-174
PMID28115039
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Mitochondria are cytosolic organelles essential for generating energy and
maintaining cell homeostasis. Despite their critical function, the handful of
proteins expressed by the mitochondrial genome is insufficient to maintain
mitochondrial structure or activity. Accordingly, mitochondrial metabolism is
fully dependent on factors encoded by the nuclear DNA, including many proteins
synthesized in the cytosol and imported into mitochondria via established
mechanisms. However, there is growing evidence that mammalian mitochondria can
also import cytosolic noncoding RNA via poorly understood processes. Here, we
summarize our knowledge of mitochondrial RNA, discuss recent progress in
understanding the molecular mechanisms and functional impact of RNA import into
mitochondria, and identify rising challenges and opportunities in this rapidly
evolving field. [BMB Reports 2017; 50(4): 164-174].