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10.2741/3539 http://scihub22266oqcxt.onion/10.2741/3539 C4570492!4570492 !19273361     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\19273361 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Biosci+(Landmark+Ed) 2009 ; 14 (12 ): 4436-43 Nephropedia Template TP {{tp|p=19273361 |t=2009. Mitochondrial nitric oxide synthase: current concepts and controversies |pdf=|usr=}}{{19273361 }} gab.com Text Mitochondrial nitric oxide synthase: current concepts and controversies JO: Front Biosci (Landmark Ed) http://www.kidney.de/pget.php?&tw=1&pmid=19273361 #FOAvip New discoveries in the last decade significantly altered our view on mitochondria. They are no longer viewed as energy-making slaves but rather individual cells-within-the-cell. In particular, it has been suggested that many important cellular mechanisms involving specific enzymes and ion channels, such as nitric oxide synthase (NOS), ATP-dependent K+ (KATP) channels, and poly-(APD-ribose) polymerase (PARP), have a distinct, mitochondrial variant. Unfortunately, exploring these parallel systems in mitochondria have technical limitations and inappropriate methods often led to inconsistent results. For example, the intriguing possibility that mitochondria are significant sources of nitric oxide (NO) via a unique mitochondrial NOS variant has attracted intense interest among research groups because of the potential for NO to affect functioning of the electron transport chain. Nonetheless, conclusive evidence concerning the existence of mitochondrial NO synthesis is yet to be presented. This review summarizes the experimental evidence gathered over the last decade in this field and highlights new areas of research that reveal surprising dimensions of NO production and metabolism by mitochondria. Twit Text FOAVip Mitochondrial nitric oxide synthase: current concepts and controversies ????Front Biosci (Landmark Ed) http://www.kidney.de/pget.php?&tw=1&pmid=19273361 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19273361 #FOAvip English Wikipedia <ref>{{Cite pmid|19273361 }}</ref> Mitochondrial nitric oxide synthase: current concepts and controversies #MMPMID19273361 Lacza Z ; Pankotai E ; Busija DW Front Biosci (Landmark Ed) 2009[Jan]; 14 (12 ): 4436-43 PMID19273361 show ga New discoveries in the last decade significantly altered our view on mitochondria. They are no longer viewed as energy-making slaves but rather individual cells-within-the-cell. In particular, it has been suggested that many important cellular mechanisms involving specific enzymes and ion channels, such as nitric oxide synthase (NOS), ATP-dependent K+ (KATP) channels, and poly-(APD-ribose) polymerase (PARP), have a distinct, mitochondrial variant. Unfortunately, exploring these parallel systems in mitochondria have technical limitations and inappropriate methods often led to inconsistent results. For example, the intriguing possibility that mitochondria are significant sources of nitric oxide (NO) via a unique mitochondrial NOS variant has attracted intense interest among research groups because of the potential for NO to affect functioning of the electron transport chain. Nonetheless, conclusive evidence concerning the existence of mitochondrial NO synthesis is yet to be presented. This review summarizes the experimental evidence gathered over the last decade in this field and highlights new areas of research that reveal surprising dimensions of NO production and metabolism by mitochondria. |Animals [MESH] |Humans [MESH] |Mitochondria/*enzymology [MESH] |Nitric Oxide Synthase/*metabolism [MESH]Mitochondrial nitric oxide synthase: current concepts and controversie(epmc).pdf DeepDyve Pubget Overpricing