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Mitochondrial metabolism and cancer
#MMPMID29219147
Porporato PE
; Filigheddu N
; Pedro JMB
; Kroemer G
; Galluzzi L
Cell Res
2018[Mar]; 28
(3
): 265-280
PMID29219147
show ga
Glycolysis has long been considered as the major metabolic process for energy
production and anabolic growth in cancer cells. Although such a view has been
instrumental for the development of powerful imaging tools that are still used in
the clinics, it is now clear that mitochondria play a key role in oncogenesis.
Besides exerting central bioenergetic functions, mitochondria provide indeed
building blocks for tumor anabolism, control redox and calcium homeostasis,
participate in transcriptional regulation, and govern cell death. Thus,
mitochondria constitute promising targets for the development of novel anticancer
agents. However, tumors arise, progress, and respond to therapy in the context of
an intimate crosstalk with the host immune system, and many immunological
functions rely on intact mitochondrial metabolism. Here, we review the cancer
cell-intrinsic and cell-extrinsic mechanisms through which mitochondria influence
all steps of oncogenesis, with a focus on the therapeutic potential of targeting
mitochondrial metabolism for cancer therapy.
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