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10.1007/s00204-014-1239-1 http://scihub22266oqcxt.onion/10.1007/s00204-014-1239-1 C4274771!4274771 !24859930     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24859930 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Arch+Toxicol 2014 ; 88 (6 ): 1249-56 Nephropedia Template TP {{tp|p=24859930 |t=2014. Mitochondrial dysregulation and protection in cisplatin nephrotoxicity |pdf=|usr=}}{{24859930 }} gab.com Text Mitochondrial dysregulation and protection in cisplatin nephrotoxicity JO: Arch Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=24859930 #FOAvip Nephrotoxicity is a major side effect of cisplatin in chemotherapy. Pathologically, cisplatin nephrotoxicity is characterized by cell injury and death in renal tubules. The research in the past decade has gained significant understanding of the cellular and molecular mechanisms of tubular cell death, revealing a central role of mitochondrial dysregulation. The pathological changes in mitochondria in cisplatin nephrotoxicity are mainly triggered by DNA damage response, pro-apoptotic protein attack, disruption of mitochondrial dynamics, and oxidative stress. As such, inhibitory strategies targeting these cytotoxic events may provide renal protection. Nonetheless, ideal approaches for renoprotection should not only protect kidneys but also enhance the anticancer efficacy of cisplatin in chemotherapy. Twit Text FOAVip Mitochondrial dysregulation and protection in cisplatin nephrotoxicity ????Arch Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=24859930 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24859930 #FOAvip English Wikipedia <ref>{{Cite pmid|24859930 }}</ref> Mitochondrial dysregulation and protection in cisplatin nephrotoxicity #MMPMID24859930 Yang Y ; Liu H ; Liu F ; Dong Z Arch Toxicol 2014[Jun]; 88 (6 ): 1249-56 PMID24859930 show ga Nephrotoxicity is a major side effect of cisplatin in chemotherapy. Pathologically, cisplatin nephrotoxicity is characterized by cell injury and death in renal tubules. The research in the past decade has gained significant understanding of the cellular and molecular mechanisms of tubular cell death, revealing a central role of mitochondrial dysregulation. The pathological changes in mitochondria in cisplatin nephrotoxicity are mainly triggered by DNA damage response, pro-apoptotic protein attack, disruption of mitochondrial dynamics, and oxidative stress. As such, inhibitory strategies targeting these cytotoxic events may provide renal protection. Nonetheless, ideal approaches for renoprotection should not only protect kidneys but also enhance the anticancer efficacy of cisplatin in chemotherapy. |Animals [MESH] |Antineoplastic Agents/adverse effects [MESH] |Apoptosis/drug effects [MESH] |Cisplatin/*adverse effects [MESH] |DNA Damage/drug effects [MESH] |Humans [MESH] |Kidney Diseases/*chemically induced/physiopathology/prevention & control [MESH] |Mitochondria/*drug effects/pathology [MESH]Mitochondrial dysregulation and protection in cisplatin nephrotoxicity(epmc).pdf DeepDyve Pubget Overpricing