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10.1016/j.beem.2012.05.004 http://scihub22266oqcxt.onion/10.1016/j.beem.2012.05.004 C5967392!5967392 !23168275     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23168275 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Best+Pract+Res+Clin+Endocrinol+Metab 2012 ; 26 (6 ): 725-38 Nephropedia Template TP {{tp|p=23168275 |t=2012. Mitochondrial dynamics and morphology in beta-cells |pdf=|usr=}}{{23168275 }} gab.com Text Mitochondrial dynamics and morphology in beta-cells JO: Best Pract Res Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=23168275 #FOAvip Mitochondrial dynamics contribute to the regulation of mitochondrial shape as well as various mitochondrial functions and quality control. This is of particular interest in the beta-cell because of the key role mitochondria play in the regulation of beta-cell insulin secretion function. Moreover, mitochondrial dysfunction has been suggested to contribute to the development of Type 2 Diabetes. Genetic tools that shift the balance of mitochondrial fusion and fission result in alterations to beta-cell function and viability. Additionally, conditions that induce beta-cell dysfunction, such as exposure to a high nutrient environment, disrupt mitochondrial morphology and dynamics. While it has been shown that mitochondria display a fragmented morphology in islets of diabetic patients and animal models, the mechanism behind this is currently unknown. Here, we review the current literature on mitochondrial morphology and dynamics in the beta-cell as well as some of the unanswered question in this field. Twit Text FOAVip Mitochondrial dynamics and morphology in beta-cells ????Best Pract Res Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=23168275 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23168275 #FOAvip English Wikipedia <ref>{{Cite pmid|23168275 }}</ref> Mitochondrial dynamics and morphology in beta-cells #MMPMID23168275 Stiles L ; Shirihai OS Best Pract Res Clin Endocrinol Metab 2012[Dec]; 26 (6 ): 725-38 PMID23168275 show ga Mitochondrial dynamics contribute to the regulation of mitochondrial shape as well as various mitochondrial functions and quality control. This is of particular interest in the beta-cell because of the key role mitochondria play in the regulation of beta-cell insulin secretion function. Moreover, mitochondrial dysfunction has been suggested to contribute to the development of Type 2 Diabetes. Genetic tools that shift the balance of mitochondrial fusion and fission result in alterations to beta-cell function and viability. Additionally, conditions that induce beta-cell dysfunction, such as exposure to a high nutrient environment, disrupt mitochondrial morphology and dynamics. While it has been shown that mitochondria display a fragmented morphology in islets of diabetic patients and animal models, the mechanism behind this is currently unknown. Here, we review the current literature on mitochondrial morphology and dynamics in the beta-cell as well as some of the unanswered question in this field. |Animals [MESH] |Autophagy/physiology [MESH] |Diabetes Mellitus, Type 2/pathology [MESH] |Humans [MESH] |Insulin-Secreting Cells/*physiology [MESH] |Mitochondria/*physiology/ultrastructure [MESH] |Mitochondrial Dynamics/physiology [MESH]Mitochondrial dynamics and morphology in beta-cells (epmc).pdf DeepDyve Pubget Overpricing