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2016 ; 73
(24
): 4577-4590
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Mitochondrial cAMP signaling
#MMPMID27233501
Zhang F
; Zhang L
; Qi Y
; Xu H
Cell Mol Life Sci
2016[Dec]; 73
(24
): 4577-4590
PMID27233501
show ga
Cyclic adenosine 3, 5'-monophosphate (cAMP) is a ubiquitous second messenger
regulating many biological processes, such as cell migration, differentiation,
proliferation and apoptosis. cAMP signaling functions not only on the plasma
membrane, but also in the nucleus and in organelles such as mitochondria.
Mitochondrial cAMP signaling is an indispensable part of the
cytoplasm-mitochondrion crosstalk that maintains mitochondrial homeostasis,
regulates mitochondrial dynamics, and modulates cellular stress responses and
other signaling pathways. Recently, the compartmentalization of mitochondrial
cAMP signaling has attracted great attentions. This new input should be carefully
taken into account when we interpret the findings of mitochondrial cAMP
signaling. In this review, we summarize previous and recent progress in our
understanding of mitochondrial cAMP signaling, including the components of the
signaling cascade, and the function and regulation of this signaling pathway in
different mitochondrial compartments.