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10.1126/science.aaa0986 http://scihub22266oqcxt.onion/10.1126/science.aaa0986 C4677687!4677687 !25635099     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25635099 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Science 2015 ; 347 (6221 ): 548-51 Nephropedia Template TP {{tp|p=25635099 |t=2015. Mitochondrial biology Replication-transcription switch in human mitochondria |pdf=|usr=}}{{25635099 }} gab.com Text Mitochondrial biology Replication-transcription switch in human mitochondria JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=25635099 #FOAvip Coordinated replication and expression of the mitochondrial genome is critical for metabolically active cells during various stages of development. However, it is not known whether replication and transcription can occur simultaneously without interfering with each other and whether mitochondrial DNA copy number can be regulated by the transcription machinery. We found that interaction of human transcription elongation factor TEFM with mitochondrial RNA polymerase and nascent transcript prevents the generation of replication primers and increases transcription processivity and thereby serves as a molecular switch between replication and transcription, which appear to be mutually exclusive processes in mitochondria. TEFM may allow mitochondria to increase transcription rates and, as a consequence, respiration and adenosine triphosphate production without the need to replicate mitochondrial DNA, as has been observed during spermatogenesis and the early stages of embryogenesis. Twit Text FOAVip Mitochondrial biology Replication-transcription switch in human mitochondria ????Science http://www.kidney.de/pget.php?&tw=1&pmid=25635099 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25635099 #FOAvip English Wikipedia <ref>{{Cite pmid|25635099 }}</ref> Mitochondrial biology Replication-transcription switch in human mitochondria #MMPMID25635099 Agaronyan K ; Morozov YI ; Anikin M ; Temiakov D Science 2015[Jan]; 347 (6221 ): 548-51 PMID25635099 show ga Coordinated replication and expression of the mitochondrial genome is critical for metabolically active cells during various stages of development. However, it is not known whether replication and transcription can occur simultaneously without interfering with each other and whether mitochondrial DNA copy number can be regulated by the transcription machinery. We found that interaction of human transcription elongation factor TEFM with mitochondrial RNA polymerase and nascent transcript prevents the generation of replication primers and increases transcription processivity and thereby serves as a molecular switch between replication and transcription, which appear to be mutually exclusive processes in mitochondria. TEFM may allow mitochondria to increase transcription rates and, as a consequence, respiration and adenosine triphosphate production without the need to replicate mitochondrial DNA, as has been observed during spermatogenesis and the early stages of embryogenesis. |*DNA Replication [MESH] |*Transcription, Genetic [MESH] |DNA, Mitochondrial/*genetics/*metabolism [MESH] |DNA-Directed RNA Polymerases/chemistry/*metabolism [MESH] |G-Quadruplexes [MESH] |Genome, Mitochondrial [MESH] |Humans [MESH] |Mitochondria/genetics/metabolism [MESH] |Mitochondrial Proteins/chemistry/*metabolism [MESH] |Models, Genetic [MESH] |Models, Molecular [MESH] |RNA, Mitochondrial [MESH] |RNA/chemistry/*metabolism [MESH] |Transcription Factors/*metabolism [MESH]Mitochondrial biology Replication-transcription switch in human mitoc(epmc).pdf DeepDyve Pubget Overpricing