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2015 ; 29
(9
): 631-8
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Mitochondrial Replacement: Ethics and Identity
#MMPMID26481204
Wrigley A
; Wilkinson S
; Appleby JB
Bioethics
2015[Nov]; 29
(9
): 631-8
PMID26481204
show ga
Mitochondrial replacement techniques (MRTs) have the potential to allow
prospective parents who are at risk of passing on debilitating or even
life-threatening mitochondrial disorders to have healthy children to whom they
are genetically related. Ethical concerns have however been raised about these
techniques. This article focuses on one aspect of the ethical debate, the
question of whether there is any moral difference between the two types of MRT
proposed: Pronuclear Transfer (PNT) and Maternal Spindle Transfer (MST). It
examines how questions of identity impact on the ethical evaluation of each
technique and argues that there is an important difference between the two. PNT,
it is argued, is a form of therapy based on embryo modification while MST is,
instead, an instance of selective reproduction. The article's main ethical
conclusion is that, in some circumstances, there is a stronger obligation to use
PNT than MST.