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2017 ; 28
(10
): 748-757
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Mitochondrial Metabolism: Yin and Yang for Tumor Progression
#MMPMID28938972
Valcarcel-Jimenez L
; Gaude E
; Torrano V
; Frezza C
; Carracedo A
Trends Endocrinol Metab
2017[Oct]; 28
(10
): 748-757
PMID28938972
show ga
Altered metabolism is a distinct feature of cancer cells. During transformation,
the entire metabolic network is rewired to efficiently convert nutrients to
biosynthetic precursors to sustain cancer cell growth and proliferation. Whilst
the molecular underpinnings of this metabolic reprogramming have been described,
its role in tumor progression is still under investigation. Importantly, the
mitochondrion is a central actor in many of the metabolic processes that are
altered in tumors. Yet, we have only begun to understand the dualities of
mitochondrial function during cancer metastasis and therapy resistance.
Paradoxically, mitochondrial metabolism can be both advantageous and detrimental
to these processes, highlighting the need for a better understanding of the
molecular and microenvironmental cues that define the role of this fascinating
organelle. In this review article, we present an updated view on the different
mitochondrial metabolic strategies adopted by cancer cells to overcome the many
hurdles faced during tumor progression.
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