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10.3390/ijms160817763 http://scihub22266oqcxt.onion/10.3390/ijms160817763 C4581220!4581220 !26247933     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26247933 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26247933 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2015 ; 16 (8 ): 17763-78 Nephropedia Template TP {{tp|p=26247933 |t=2015. Mitochondrial Mechanisms in Septic Cardiomyopathy |pdf=|usr=}}{{26247933 }} gab.com Text Mitochondrial Mechanisms in Septic Cardiomyopathy JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26247933 #FOAvip Sepsis is the manifestation of the immune and inflammatory response to infection that may ultimately result in multi organ failure. Despite the therapeutic strategies that have been used up to now, sepsis and septic shock remain a leading cause of death in critically ill patients. Myocardial dysfunction is a well-described complication of severe sepsis, also referred to as septic cardiomyopathy, which may progress to right and left ventricular pump failure. Many substances and mechanisms seem to be involved in myocardial dysfunction in sepsis, including toxins, cytokines, nitric oxide, complement activation, apoptosis and energy metabolic derangements. Nevertheless, the precise underlying molecular mechanisms as well as their significance in the pathogenesis of septic cardiomyopathy remain incompletely understood. A well-investigated abnormality in septic cardiomyopathy is mitochondrial dysfunction, which likely contributes to cardiac dysfunction by causing myocardial energy depletion. A number of mechanisms have been proposed to cause mitochondrial dysfunction in septic cardiomyopathy, although it remains controversially discussed whether some mechanisms impair mitochondrial function or serve to restore mitochondrial function. The purpose of this review is to discuss mitochondrial mechanisms that may causally contribute to mitochondrial dysfunction and/or may represent adaptive responses to mitochondrial dysfunction in septic cardiomyopathy. Twit Text FOAVip Mitochondrial Mechanisms in Septic Cardiomyopathy ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26247933 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26247933 #FOAvip English Wikipedia <ref>{{Cite pmid|26247933 }}</ref> Mitochondrial Mechanisms in Septic Cardiomyopathy #MMPMID26247933 Cimolai MC ; Alvarez S ; Bode C ; Bugger H Int J Mol Sci 2015[Aug]; 16 (8 ): 17763-78 PMID26247933 show ga Sepsis is the manifestation of the immune and inflammatory response to infection that may ultimately result in multi organ failure. Despite the therapeutic strategies that have been used up to now, sepsis and septic shock remain a leading cause of death in critically ill patients. Myocardial dysfunction is a well-described complication of severe sepsis, also referred to as septic cardiomyopathy, which may progress to right and left ventricular pump failure. Many substances and mechanisms seem to be involved in myocardial dysfunction in sepsis, including toxins, cytokines, nitric oxide, complement activation, apoptosis and energy metabolic derangements. Nevertheless, the precise underlying molecular mechanisms as well as their significance in the pathogenesis of septic cardiomyopathy remain incompletely understood. A well-investigated abnormality in septic cardiomyopathy is mitochondrial dysfunction, which likely contributes to cardiac dysfunction by causing myocardial energy depletion. A number of mechanisms have been proposed to cause mitochondrial dysfunction in septic cardiomyopathy, although it remains controversially discussed whether some mechanisms impair mitochondrial function or serve to restore mitochondrial function. The purpose of this review is to discuss mitochondrial mechanisms that may causally contribute to mitochondrial dysfunction and/or may represent adaptive responses to mitochondrial dysfunction in septic cardiomyopathy. |Animals [MESH] |Calcium Signaling [MESH] |Cardiomyopathies/etiology/*metabolism [MESH] |Humans [MESH] |Mitochondria/*metabolism [MESH] |Mitochondrial Turnover [MESH] |Oxidative Stress [MESH]Mitochondrial Mechanisms in Septic Cardiomyopathy (epmc).pdf DeepDyve Pubget Overpricing