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2015 ; 6
(1
): 507-26
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Mitochondrial Dynamics and Heart Failure
#MMPMID26756641
Knowlton AA
; Liu TT
Compr Physiol
2015[Dec]; 6
(1
): 507-26
PMID26756641
show ga
Mitochondrial dynamics, fission and fusion, were first identified in yeast with
investigation in heart cells beginning only in the last 5 to 7 years. In the
ensuing time, it has become evident that these processes are not only required
for healthy mitochondria, but also, that derangement of these processes
contributes to disease. The fission and fusion proteins have a number of
functions beyond the mitochondrial dynamics. Many of these functions are related
to their membrane activities, such as apoptosis. However, other functions involve
other areas of the mitochondria, such as OPA1's role in maintaining cristae
structure and preventing cytochrome c leak, and its essential (at least a 10 kDa
fragment of OPA1) role in mtDNA replication. In heart disease, changes in
expression of these important proteins can have detrimental effects on
mitochondrial and cellular function.
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