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2016 ; 2016
(ä): 7869174
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Mitochondrial Disorder Aggravated by Metoprolol
#MMPMID27840760
Samuels C
; Koenig MK
; Hernandez M
; Yadav A
; Mosquera RA
Case Rep Pediatr
2016[]; 2016
(ä): 7869174
PMID27840760
show ga
Beta-adrenergic blocking agents or beta-blockers are a class of medications used
to treat cardiac arrhythmias and systemic hypertension. In therapeutic dosages,
they have known adverse outcomes that can include muscular fatigue and cramping,
dizziness, and dyspnea. In patients with mitochondrial disease, these effects can
be amplified. Previous case reports have been published in the adult population;
however, their impact in pediatric patients has not been reported. We describe a
pediatric patient with a mitochondrial disorder who developed respiratory
distress after metoprolol was prescribed for hypertension. As the patient
improved with discontinuation of medication and no alternative etiology was found
for symptoms, we surmise that administration of metoprolol aggravated his
mitochondrial dysfunction, thus worsening underlying chest wall weakness.