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Mitochondrial Control of Innate Immunity and Inflammation
#MMPMID28458619
Jin HS
; Suh HW
; Kim SJ
; Jo EK
Immune Netw
2017[Apr]; 17
(2
): 77-88
PMID28458619
show ga
Mitochondria are key organelles involved in energy production, functioning as the
metabolic hubs of cells. Recent findings emphasize the emerging role of the
mitochondrion as a key intracellular signaling platform regulating innate immune
and inflammatory responses. Several mitochondrial proteins and mitochondrial
reactive oxygen species have emerged as central players orchestrating the innate
immune responses to pathogens and damaging ligands. This review explores our
current understanding of the roles played by mitochondria in regulation of innate
immunity and inflammatory responses. Recent advances in our understanding of the
relationship between autophagy, mitochondria, and inflammasome activation are
also briefly discussed. A comprehensive understanding of mitochondrial role in
toll-like receptor-mediated innate immune responses and NLRP3 inflammasome
complex activation, will facilitate development of novel therapeutics to treat
various infectious, inflammatory, and autoimmune disorders.
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