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2014 ; 9
(16
): 2531-43
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Mitochondria-targeting particles
#MMPMID25490424
Wongrakpanich A
; Geary SM
; Joiner ML
; Anderson ME
; Salem AK
Nanomedicine (Lond)
2014[Nov]; 9
(16
): 2531-43
PMID25490424
show ga
Mitochondria are a promising therapeutic target for the detection, prevention and
treatment of various human diseases such as cancer, neurodegenerative diseases,
ischemia-reperfusion injury, diabetes and obesity. To reach mitochondria,
therapeutic molecules need to not only gain access to specific organs, but also
to overcome multiple barriers such as the cell membrane and the outer and inner
mitochondrial membranes. Cellular and mitochondrial barriers can be potentially
overcome through the design of mitochondriotropic particulate carriers capable of
transporting drug molecules selectively to mitochondria. These particulate
carriers or vectors can be made from lipids (liposomes), biodegradable polymers,
or metals, protecting the drug cargo from rapid elimination and degradation in
vivo. Many formulations can be tailored to target mitochondria by the
incorporation of mitochondriotropic agents onto the surface and can be
manufactured to desired sizes and molecular charge. Here, we summarize recently
reported strategies for delivering therapeutic molecules to mitochondria using
various particle-based formulations.
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