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2015 ; 7
(ä): 42
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Mitochondria and apoptosis: emerging concepts
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Li MX
; Dewson G
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2015[]; 7
(ä): 42
PMID26097715
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As mitochondria are the powerhouses of the cell, their damage during the cell
suicide process of apoptosis is essentially responsible for cellular demise in
most cells. A key family of proteins, the B-cell lymphoma-2 (BCL-2) family,
determines the integrity of mitochondria in the face of apoptotic insult. A
comprehensive understanding of the molecular details of how apoptosis is
initiated and how it culminates is essential if apoptosis is to fulfil its
undoubted potential as a therapeutic target to treat diseases ranging from cancer
to neurodegenerative conditions. Recent advances have provided significant
insight into the control of this fundamental process while prompting a
re-evaluation of what was considered dogma in the field. Emerging evidence also
points to a potential overarching control network that governs not only apoptosis
but other fundamental mitochondrial processes, including mitochondrial
fission/fusion and quality control.