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2016 ; 166
(3
): 555-566
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Mitochondria and Cancer
#MMPMID27471965
Vyas S
; Zaganjor E
; Haigis MC
Cell
2016[Jul]; 166
(3
): 555-566
PMID27471965
show ga
Mitochondria are bioenergetic, biosynthetic, and signaling organelles that are
integral in stress sensing to allow for cellular adaptation to the environment.
Therefore, it is not surprising that mitochondria are important mediators of
tumorigenesis, as this process requires flexibility to adapt to cellular and
environmental alterations in addition to cancer treatments. Multiple aspects of
mitochondrial biology beyond bioenergetics support transformation, including
mitochondrial biogenesis and turnover, fission and fusion dynamics, cell death
susceptibility, oxidative stress regulation, metabolism, and signaling. Thus,
understanding mechanisms of mitochondrial function during tumorigenesis will be
critical for the next generation of cancer therapeutics.