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10.1016/j.cell.2016.07.002

http://scihub22266oqcxt.onion/10.1016/j.cell.2016.07.002
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C5036969!5036969 !27471965
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suck abstract from ncbi


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      Cell 2016 ; 166 (3 ): 555-566
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  • Mitochondria and Cancer #MMPMID27471965
  • Vyas S ; Zaganjor E ; Haigis MC
  • Cell 2016[Jul]; 166 (3 ): 555-566 PMID27471965 show ga
  • Mitochondria are bioenergetic, biosynthetic, and signaling organelles that are integral in stress sensing to allow for cellular adaptation to the environment. Therefore, it is not surprising that mitochondria are important mediators of tumorigenesis, as this process requires flexibility to adapt to cellular and environmental alterations in addition to cancer treatments. Multiple aspects of mitochondrial biology beyond bioenergetics support transformation, including mitochondrial biogenesis and turnover, fission and fusion dynamics, cell death susceptibility, oxidative stress regulation, metabolism, and signaling. Thus, understanding mechanisms of mitochondrial function during tumorigenesis will be critical for the next generation of cancer therapeutics.
  • |*Carcinogenesis [MESH]
  • |Animals [MESH]
  • |Humans [MESH]


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