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10.1016/j.febslet.2014.08.035

http://scihub22266oqcxt.onion/10.1016/j.febslet.2014.08.035
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suck abstract from ncbi


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pmid25220850
      FEBS+Lett 2014 ; 588 (23 ): 4305-10
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  • Mistranslation of the genetic code #MMPMID25220850
  • Moghal A ; Mohler K ; Ibba M
  • FEBS Lett 2014[Nov]; 588 (23 ): 4305-10 PMID25220850 show ga
  • During mRNA decoding at the ribosome, deviations from stringent codon identity, or "mistranslation," are generally deleterious and infrequent. Observations of organisms that decode some codons ambiguously, and the discovery of a compensatory increase in mistranslation frequency to combat environmental stress have changed the way we view "errors" in decoding. Modern tools for the study of the frequency and phenotypic effects of mistranslation can provide quantitative and sensitive measurements of decoding errors that were previously inaccessible. Mistranslation with non-protein amino acids, in particular, is an enticing prospect for new drug therapies and the study of molecular evolution.
  • |Animals [MESH]
  • |Cells/metabolism [MESH]
  • |Codon/genetics [MESH]
  • |Evolution, Molecular [MESH]
  • |Genetic Code/*genetics [MESH]
  • |Humans [MESH]
  • |Mass Spectrometry [MESH]


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