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2014 ; 588
(23
): 4305-10
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Mistranslation of the genetic code
#MMPMID25220850
Moghal A
; Mohler K
; Ibba M
FEBS Lett
2014[Nov]; 588
(23
): 4305-10
PMID25220850
show ga
During mRNA decoding at the ribosome, deviations from stringent codon identity,
or "mistranslation," are generally deleterious and infrequent. Observations of
organisms that decode some codons ambiguously, and the discovery of a
compensatory increase in mistranslation frequency to combat environmental stress
have changed the way we view "errors" in decoding. Modern tools for the study of
the frequency and phenotypic effects of mistranslation can provide quantitative
and sensitive measurements of decoding errors that were previously inaccessible.
Mistranslation with non-protein amino acids, in particular, is an enticing
prospect for new drug therapies and the study of molecular evolution.