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2015 ; 6
(ä): 1665
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Mirror neuron system based therapy for aphasia rehabilitation
#MMPMID26579046
Chen W
; Ye Q
; Ji X
; Zhang S
; Yang X
; Zhou Q
; Cong F
; Chen W
; Zhang X
; Zhang B
; Xia Y
; Yuan TF
; Shan C
Front Psychol
2015[]; 6
(ä): 1665
PMID26579046
show ga
OBJECTIVE: To investigate the effect of hand action observation training, i.e.,
mirror neuron system (MNS) based training, on language function of aphasic
patients after stroke. In addition, to reveal the tentative mechanism underlying
this effect. METHODS: Six aphasic patients after stroke, meeting the criteria,
undergo 3 weeks' training protocol (30 min per day, 6 days per week). Among them,
four patients accepted an ABA training design, i.e., they implemented Protocol A
(hand action observation combined with repetition) in the first and third weeks
and carried out Protocol B (static object observation combined with repetition)
in the second week. Conversely, for the other two patients, BAB training design
was adopted, i.e., patients took Protocol B in the first and third weeks and
accepted Protocol A in the second week. Picture naming test, western aphasia
battery (WAB) and Token Test were applied to evaluate the changes of language
function before and after each week's training. Furthermore, two subjects (one
aphasic patient and one healthy volunteer) attended a functional MRI (fMRI)
experiment, by which we tried to reveal the mechanism underlying possible
language function changes after training. RESULTS: Compared with static object
observation and repetition training (Protocol B), hand action observation and
repetition training (Protocol A) effectively improved most aspects of the
language function in all six patients, as demonstrated in the picture naming
test, subtests of oral language and aphasia quotient (AQ) of WAB. In addition,
the fMRI experiment showed that Protocol A induced more activations in the MNS of
one patient and one healthy control when compared to Protocol B. CONCLUSION: The
mirror neuron based therapy may facilitate the language recovery for aphasic
patients and this, to some extent, provides a novel direction of rehabilitation
for aphasia patients.