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10.1080/23723556.2015.1019974

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suck abstract from ncbi


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pmid27308581
      Mol+Cell+Oncol 2016 ; 3 (2 ): e1019974
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  • Mirror image phosphoinositides regulate autophagy #MMPMID27308581
  • Vicinanza M ; Rubinsztein DC
  • Mol Cell Oncol 2016[Mar]; 3 (2 ): e1019974 PMID27308581 show ga
  • Autophagosome formation is stimulated by canonical VPS34-dependent formation of phosphatidylinositol 3-phosphate [PI(3)P], which recruits effectors such as WIPI2. However, non-canonical VPS34-independent autophagy has also been proposed. We recently described that PI(5)P regulates autophagosome biogenesis, recruits WIPI2, and rescues autophagy in VPS34-inactivated cells. These alternative autophagy-initiating pathways reveal new druggable targets for treating neurodegeneration and cancer.
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