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10.1210/me.2015-1033 http://scihub22266oqcxt.onion/10.1210/me.2015-1033 C4399280!4399280 !25730708     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25730708 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Endocrinol 2015 ; 29 (4 ): 490-501 Nephropedia Template TP {{tp|p=25730708 |t=2015. Minireview: translocator protein (TSPO) and steroidogenesis: a reappraisal |pdf=|usr=}}{{25730708 }} gab.com Text Minireview: translocator protein (TSPO) and steroidogenesis: a reappraisal JO: Mol Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=25730708 #FOAvip The 18-kDa translocator protein (TSPO), also known as the peripheral benzodiazepine receptor, is a transmembrane protein in the outer mitochondrial membrane. TSPO has long been described as being indispensable for mitochondrial cholesterol import that is essential for steroid hormone production. In contrast to this initial proposition, recent experiments reexamining TSPO function have demonstrated that it is not involved in steroidogenesis. This fundamental change has forced a reexamination of the functional interpretations made for TSPO that broadly impacts both basic and clinical research across multiple fields. In this minireview, we recapitulate the key studies from 25 years of TSPO research and concurrently examine their limitations that perhaps led towards the incorrect association of TSPO and steroid hormone production. Although this shift in understanding raises new questions regarding the molecular function of TSPO, these recent developments are poised to have a significant positive impact for research progress in steroid endocrinology. Twit Text FOAVip Minireview: translocator protein (TSPO) and steroidogenesis: a reappraisal ????Mol Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=25730708 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25730708 #FOAvip English Wikipedia <ref>{{Cite pmid|25730708 }}</ref> Minireview: translocator protein (TSPO) and steroidogenesis: a reappraisal #MMPMID25730708 Selvaraj V ; Stocco DM ; Tu LN Mol Endocrinol 2015[Apr]; 29 (4 ): 490-501 PMID25730708 show ga The 18-kDa translocator protein (TSPO), also known as the peripheral benzodiazepine receptor, is a transmembrane protein in the outer mitochondrial membrane. TSPO has long been described as being indispensable for mitochondrial cholesterol import that is essential for steroid hormone production. In contrast to this initial proposition, recent experiments reexamining TSPO function have demonstrated that it is not involved in steroidogenesis. This fundamental change has forced a reexamination of the functional interpretations made for TSPO that broadly impacts both basic and clinical research across multiple fields. In this minireview, we recapitulate the key studies from 25 years of TSPO research and concurrently examine their limitations that perhaps led towards the incorrect association of TSPO and steroid hormone production. Although this shift in understanding raises new questions regarding the molecular function of TSPO, these recent developments are poised to have a significant positive impact for research progress in steroid endocrinology. |Animals [MESH] |Biological Transport/physiology [MESH] |Cholesterol/*metabolism [MESH] |Gonadal Steroid Hormones/*biosynthesis [MESH] |Humans [MESH]Minireview: translocator protein (TSPO) and steroidogenesis: a reappra(epmc).pdf DeepDyve Pubget Overpricing