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2017 ; 345
(ä): 77-88
Nephropedia Template TP
Neuroscience
2017[Mar]; 345
(ä): 77-88
PMID26868974
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The role of the thalamus in complex cognitive behavior is a topic of increasing
interest. Here we demonstrate that lesions of the nucleus reuniens (NRe), a
midline thalamic nucleus interconnected with both hippocampal and prefrontal
circuitry, lead to enhancement of executive behaviors typically associated with
the prefrontal cortex. Rats were tested on four behavioral tasks: (1) the
combined attention-memory (CAM) task, which simultaneously assessed attention to
a visual target and memory for that target over a variable delay; (2) spatial
memory using a radial arm maze, (3) discrimination and reversal learning using a
touchscreen operant platform, and (4) decision-making with delayed outcomes.
Following NRe lesions, the animals became more efficient in their performance,
responding with shorter reaction times but also less impulsively than controls.
This change, combined with a decrease in perseverative responses, led to focused
attention in the CAM task and accelerated learning in the visual discrimination
task. There were no observed changes in tasks involving either spatial memory or
value-based decision making. These data complement ongoing efforts to understand
the role of midline thalamic structures in human cognition, including the
development of thalamic stimulation as a therapeutic strategy for acquired
cognitive disabilities (Schiff, 2008; Mair et al., 2011), and point to the NRe as
a potential target for clinical intervention.
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