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2020 ; 395
(10229
): 1063-1077
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Middle East respiratory syndrome
#MMPMID32145185
Memish ZA
; Perlman S
; Van Kerkhove MD
; Zumla A
Lancet
2020[Mar]; 395
(10229
): 1063-1077
PMID32145185
show ga
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal zoonotic
pathogen that was first identified in humans in Saudi Arabia and Jordan in 2012.
Intermittent sporadic cases, community clusters, and nosocomial outbreaks of
MERS-CoV continue to occur. Between April 2012 and December 2019, 2499
laboratory-confirmed cases of MERS-CoV infection, including 858 deaths (34·3%
mortality) were reported from 27 countries to WHO, the majority of which were
reported by Saudi Arabia (2106 cases, 780 deaths). Large outbreaks of
human-to-human transmission have occurred, the largest in Riyadh and Jeddah in
2014 and in South Korea in 2015. MERS-CoV remains a high-threat pathogen
identified by WHO as a priority pathogen because it causes severe disease that
has a high mortality rate, epidemic potential, and no medical countermeasures.
This Seminar provides an update on the current knowledge and perspectives on MERS
epidemiology, virology, mode of transmission, pathogenesis, diagnosis, clinical
features, management, infection control, development of new therapeutics and
vaccines, and highlights unanswered questions and priorities for research,
improved management, and prevention.
|*Epidemics
[MESH]
|*Middle East Respiratory Syndrome Coronavirus
[MESH]