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Mid-dermal elastolysis: A female-centric disease; case report and updated review
of the literature
#MMPMID28491975
Hardin J
; Dupuis E
; Haber RM
Int J Womens Dermatol
2015[Aug]; 1
(3
): 126-130
PMID28491975
show ga
BACKGROUND: Mid-dermal elastolysis (MDE) is a rare, yet well-defined clinical and
histopathologic entity manifested by fine wrinkling of the skin and mid-dermal
loss of elastic fibers. This disease predominantly affects young to middle-aged
Caucasian females and although it has no reported systemic features, it is
psychologically bothersome and can be of great cosmetic concern. METHODS: We
report a case of a healthy 45 year-old female with widespread mid-dermal
elastolysis. A literature search using the search terms "mid-dermal elastolysis,"
"mid dermal elastolysis," "middermal elastolysis," and "elastophagocytosis" was
conducted on Pubmed, using articles published from January 2008 until November
2014 to accompany Gambichler's comprehensive 1977 to 2009 review of mid-dermal
elastolysis. The references of relevant papers were reviewed and further cases
included as appropriate. RESULTS: We review the clinical features and
histological, ultrastructural, and immunohistochemical findings of MDE, as well
as differential diagnoses. There are 13 new publications of MDE since 2008. The
novel findings since Gambichler's review are discussed and pathomechanisms
revisited. Interestingly, given the striking female predominance of MDE, there is
no known hormonal role in its etiology.
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