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2016 ; 39
(7
): 433-440
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Microtubules and Growth Cones: Motors Drive the Turn
#MMPMID27233682
Kahn OI
; Baas PW
Trends Neurosci
2016[Jul]; 39
(7
): 433-440
PMID27233682
show ga
Navigation of the growth cone at the tip of the developing axon is crucial for
the proper wiring of the nervous system. Mechanisms of actin-dependent growth
cone steering, via signaling cascades, are well documented. Microtubules are also
important in growth cone guidance, because their polarized invasion into the
peripheral domain on one side of the growth cone is essential for it to turn in
that direction. Classically, microtubules have been considered secondary players,
invading the peripheral domain only where the actin cytoskeleton permits them to
go. Presented here is evidence for an underappreciated mechanism by which
signaling cascades can potentially affect growth cone turning, namely through
regulatable forces imposed on the microtubules by molecular motor proteins.