Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28952525
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Bioengineering+(Basel)
2017 ; 4
(2
): ä Nephropedia Template TP
Bioengineering (Basel)
2017[May]; 4
(2
): ä PMID28952525
show ga
Drugs affect the human body through absorption, distribution, metabolism, and
elimination (ADME) processes. Due to their importance, the ADME processes need to
be studied to determine the efficacy and side effects of drugs. Various in vitro
model systems have been developed and used to realize the ADME processes.
However, conventional model systems have failed to simulate the ADME processes
because they are different from in vivo, which has resulted in a high attrition
rate of drugs and a decrease in the productivity of new drug development.
Recently, a microtechnology-based in vitro system called "organ-on-a-chip" has
been gaining attention, with more realistic cell behavior and physiological
reactions, capable of better simulating the in vivo environment. Furthermore,
multi-organ-on-a-chip models that can provide information on the interaction
between the organs have been developed. The ultimate goal is the development of a
"body-on-a-chip", which can act as a whole body model. In this review, we
introduce and summarize the current progress in the development of multi-organ
models as a foundation for the development of body-on-a-chip.
free
free
free
