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10.4103/0971-5916.191801 http://scihub22266oqcxt.onion/10.4103/0971-5916.191801 C5080918!5080918 !27748284     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27748284 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Indian+J+Med+Res 2016 ; 143 (Supplement ): S104-S111 Nephropedia Template TP {{tp|p=27748284 |t=2016. Microsatellite instability & survival in patients with stage II/III colorectal carcinoma |pdf=|usr=}}{{27748284 }} gab.com Text Microsatellite instability & survival in patients with stage II/III colorectal carcinoma JO: Indian J Med Res http://www.kidney.de/pget.php?&tw=1&pmid=27748284 #FOAvip BACKGROUND & OBJECTIVES: The two key aspects associated with the microsatellite instability (MSI) as genetic phenomenon in colorectal cancer (CRC) are better survival prognosis, and the varying response to 5-fluorouracil (5-FU)-based chemotherapy. This study was undertaken to measure the survival of surgically treated patients with stages II and III CRC based on the MSI status, the postoperative 5-FU treatment as well as clinical and histological data. METHODS: A total of 125 consecutive patients with stages II and III (American Joint Committee on Cancer, AJCC staging) primary CRCs, were followed prospectively for a median time of 31 months (January 2006 to December 2009). All patients were assessed, operated and clinically followed. Tumour samples were obtained for cytopathological verification and MSI grading. RESULTS: Of the 125 patients, 21 (20%) had high MSI (MSI-H), and 101 patients (80%) had MSI-L or MSS (low frequency MSI or stable MSI). Patients with MSS CRC were more likely to have recurrent disease (P=0.03; OR=3.2; CI 95% 1-10.2) compared to those with MSI-H CRC. Multi- and univariate Cox regression analysis failed to show a difference between MSI-H and MSS groups with respect to disease-free, disease-specific and overall survival. However, the disease-free survival was significantly lower in patients with MSI-H CRC treated by adjuvant 5-FU therapy (P=0.03). INTERPRETATION & CONCLUSIONS: MSI-H CRCs had a lower recurrence rate, but the prognosis was worse following adjuvant 5-FU therapy. Twit Text FOAVip Microsatellite instability & survival in patients with stage II/III colorectal carcinoma ????Indian J Med Res http://www.kidney.de/pget.php?&tw=1&pmid=27748284 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27748284 #FOAvip English Wikipedia <ref>{{Cite pmid|27748284 }}</ref> Microsatellite instability & survival in patients with stage II/III colorectal carcinoma #MMPMID27748284 Srdjan M ; Jadranka A ; Ivan D ; Branimir Z ; Daniela B ; Petar S ; Velimir M ; Zoran K Indian J Med Res 2016[May]; 143 (Supplement ): S104-S111 PMID27748284 show ga BACKGROUND & OBJECTIVES: The two key aspects associated with the microsatellite instability (MSI) as genetic phenomenon in colorectal cancer (CRC) are better survival prognosis, and the varying response to 5-fluorouracil (5-FU)-based chemotherapy. This study was undertaken to measure the survival of surgically treated patients with stages II and III CRC based on the MSI status, the postoperative 5-FU treatment as well as clinical and histological data. METHODS: A total of 125 consecutive patients with stages II and III (American Joint Committee on Cancer, AJCC staging) primary CRCs, were followed prospectively for a median time of 31 months (January 2006 to December 2009). All patients were assessed, operated and clinically followed. Tumour samples were obtained for cytopathological verification and MSI grading. RESULTS: Of the 125 patients, 21 (20%) had high MSI (MSI-H), and 101 patients (80%) had MSI-L or MSS (low frequency MSI or stable MSI). Patients with MSS CRC were more likely to have recurrent disease (P=0.03; OR=3.2; CI 95% 1-10.2) compared to those with MSI-H CRC. Multi- and univariate Cox regression analysis failed to show a difference between MSI-H and MSS groups with respect to disease-free, disease-specific and overall survival. However, the disease-free survival was significantly lower in patients with MSI-H CRC treated by adjuvant 5-FU therapy (P=0.03). INTERPRETATION & CONCLUSIONS: MSI-H CRCs had a lower recurrence rate, but the prognosis was worse following adjuvant 5-FU therapy. |Adult [MESH] |Aged [MESH] |Colorectal Neoplasms/*drug therapy/*genetics/pathology [MESH] |Disease-Free Survival [MESH] |Female [MESH] |Fluorouracil/therapeutic use [MESH] |Follow-Up Studies [MESH] |Humans [MESH] |Male [MESH] |Microsatellite Instability/*drug effects [MESH] |Middle Aged [MESH] |Neoplasm Recurrence, Local/*genetics/pathology [MESH] |Prognosis [MESH]Microsatellite instability & survival in patients with stage II/III co(epmc).pdf DeepDyve Pubget Overpricing