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2016 ; 33
(5
): 1055-73
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Microneedles: A New Frontier in Nanomedicine Delivery
#MMPMID26908048
Larrañeta E
; McCrudden MT
; Courtenay AJ
; Donnelly RF
Pharm Res
2016[May]; 33
(5
): 1055-73
PMID26908048
show ga
This review aims to concisely chart the development of two individual research
fields, namely nanomedicines, with specific emphasis on nanoparticles (NP) and
microparticles (MP), and microneedle (MN) technologies, which have, in the recent
past, been exploited in combinatorial approaches for the efficient delivery of a
variety of medicinal agents across the skin. This is an emerging and exciting
area of pharmaceutical sciences research within the remit of transdermal drug
delivery and as such will undoubtedly continue to grow with the emergence of new
formulation and fabrication methodologies for particles and MN. Firstly, the
fundamental aspects of skin architecture and structure are outlined, with
particular reference to their influence on NP and MP penetration. Following on
from this, a variety of different particles are described, as are the diverse
range of MN modalities currently under development. The review concludes by
highlighting some of the novel delivery systems which have been described in the
literature exploiting these two approaches and directs the reader towards
emerging uses for nanomedicines in combination with MN.
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