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Microneedles As a Delivery System for Gene Therapy
#MMPMID27303298
Chen W
; Li H
; Shi D
; Liu Z
; Yuan W
Front Pharmacol
2016[]; 7
(?): 137
PMID27303298
show ga
Gene delivery systems can be divided to two major types: vector-based (either
viral vector or non-viral vector) and physical delivery technologies. Many
physical carriers, such as electroporation, gene gun, ultrasound start to be
proved to have the potential to enable gene therapy. A relatively new physical
delivery technology for gene delivery consists of microneedles (MNs), which has
been studied in many fields and for many molecule types and indications.
Microneedles can penetrate the stratum corneum, which is the main barrier for
drug delivery through the skin with ease of administration and without
significant pain. Many different kinds of MNs, such as metal MNs, coated MNs,
dissolving MNs have turned out to be promising in gene delivery. In this review,
we discussed the potential as well as the challenges of utilizing MNs to deliver
nucleic acids for gene therapy. We also proposed that a combination of MNs and
other gene delivery approaches may lead to a better delivery system for gene
therapy.
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