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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Adv+Exp+Med+Biol
2014 ; 801
(ä): 333-8
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Microglia-Müller cell interactions in the retina
#MMPMID24664715
Wang M
; Wong WT
Adv Exp Med Biol
2014[]; 801
(ä): 333-8
PMID24664715
show ga
Microglia and Müller cells are cell types that feature prominently in responses
to disease and injury in the retina. However, their mutual interactions have not
been investigated in detail. Here, we review evidence that indicate that these
two cell populations exchange functionally significant signals under uninjured
conditions and during retinal inflammation. Under normal conditions, Müller cells
constitute a potential source of extracellular ATP that mediates the
activity-dependent regulation of microglial dynamic process motility. Following
microglial activation in inflammation, microglia can signal to Müller cells,
influencing their morphological, molecular, and functional responses.
Microglia-Müller cell interactions appear to be a mode of bi-directional
communications that help shape the overall injury response in the retina.