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2015 ; 6
(ä): 249
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Microglia Versus Myeloid Cell Nomenclature during Brain Inflammation
#MMPMID26074918
Greter M
; Lelios I
; Croxford AL
Front Immunol
2015[]; 6
(ä): 249
PMID26074918
show ga
As immune sentinels of the central nervous system (CNS), microglia not only
respond rapidly to pathological conditions but also contribute to homeostasis in
the healthy brain. In contrast to other populations of the myeloid lineage, adult
microglia derive from primitive myeloid precursors that arise in the yolk sac
early during embryonic development, after which they self-maintain locally and
independently of blood-borne myeloid precursors. Under neuro-inflammatory
conditions such as experimental autoimmune encephalomyelitis, circulating
monocytes invade the CNS parenchyma where they further differentiate into
macrophages or inflammatory dendritic cells. Often it is difficult to delineate
resident microglia from infiltrating myeloid cells using currently known markers.
Here, we will discuss the current means to reliably distinguish between these
populations, and which recent advances have helped to make clear definitions
between phenotypically similar, yet functionally diverse myeloid cell types.