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2014 ; 79-80
(ä): 68-78
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Microfluidic 3D models of cancer
#MMPMID25017040
Sung KE
; Beebe DJ
Adv Drug Deliv Rev
2014[Dec]; 79-80
(ä): 68-78
PMID25017040
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Despite advances in medicine and biomedical sciences, cancer still remains a
major health issue. Complex interactions between tumors and their
microenvironment contribute to tumor initiation and progression and also
contribute to the development of drug resistant tumor cell populations. The
complexity and heterogeneity of tumors and their microenvironment make it
challenging to both study and treat cancer. Traditional animal cancer models and
in vitro cancer models are limited in their ability to recapitulate human
structures and functions, thus hindering the identification of appropriate drug
targets and therapeutic strategies. The development and application of
microfluidic 3D cancer models have the potential to overcome some of the
limitations inherent to traditional models. This review summarizes the progress
in microfluidic 3D cancer models, their benefits, and their broad application to
basic cancer biology, drug screening, and drug discovery.
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